Report of measles virus in Japan, 2009-2011


Isolation/detection of measles virus in Japan, 2009-2011
(Data based on the reports received before February 15, 2012)
In Japan, prefectural and municipal public health institutes (PHIs) report isolation/detection of infectious agents from specimens collected by sentinel clinics and hospitals under the National Epidemiological Surveillance of Infectious Diseases, other medical institutions and health centers.
Figure 1-3. Monthly reports of measles virus isolation/detection, 2008-2011
Figure 2-3. Isolation/detection of measles virus by prefecture, 2009-2011
Figure 3-3. Monthly isolation/detection of measles virus by prefecture, 2009-2011
Figure 4-3. Monthly isolation/detection of measles virus genotype D9 by prefecture, 2009-2011
Figure 5. Age distribution of cases with measles virus inolation/detection, 2011&2012
Figure 6. Isolation/detection of measles virus by genotype and prefecture, 2011&2012

2011
  From January to December 2011, PHIs in Tokyo Metropolitan and 16 prefectures (Hokkaido, Saitama,
  Chiba, Kanagawa, Niigata, Nagano, Shizuoka, Aichi, Osaka, Hyogo, Okayama, Hiroshima, Tottori,
  Kagawa, Fukuoka and Kagoshima) reported 128 measles virus isolation/detection.
  *Measles viruses were most frequently detected from the 0-4 year olds with a peak in 1
   year olds.  However, those from adult cases in their 20's-40's occupied 43%.  Both children
   and adults should pay attention to measles.
[Genotype not typed] 3 cases; one case in April and 2 cases in May.
   In Tokyo, 3 domestic sporadic cases; one in April and 2 in May
[Genotype D4] 57 cases; one in January, one in March, 39 in April, 14 in May and 2 in October.
   In Tokyo, one case in January developed measles 2 days before a visit from UK.
   In Osaka, one case in March developed measles 3 days after returning from
   France.
   In Tokyo, 34 cases in April; one developed measles 13 days after returning from
   Germany/Switzerland/France, one developed measles 2 days after returning from France,
   one developed measles 5 days after a visit from France, 30 domestic sporadic cases and
   a family member.
   In Kanagawa, 5 domestic sporadic cases including 2 cases in a family in April.
   In Tokyo, 12 domestic sporadic cases in May.
   In Hyogo, one case in May developed measles 8 days after returning from France.
   In Hiroshima, a domestic sporadic case in May.
   In Niigata, 2 cases in October developed measles 8 days and 16 days after returning
   from New Jealand, respectively.
[Genotype D8] 9 cases; 4 in March, one in April, 2 in June, one in October and one in December.
   In Hiroshima, 4 cases in March; one developed measles 8 days after returning from Australia
   and 3 family members.
   In Tokyo, one case in April developed measles 5 days before returning from Thailand.
   In Hokkaido, 2 cases in June; one domestic sporadic case and one contact case.
   In Tottori, one case in October developed measles on the day of arrival from Bangladesh/
   Viet Nam.
   In Chiba, one domestic sporadic case in December.
[Genotype D9]49 cases; 12 in January, 9 in February, 2 in March, 4 in April, 17 in May,
   one each in June, July, August, September and October.
   In Aichi, 3 cases in January from the outbreak continued from November 2010. 
   In Tokyo, 2 cases in January; one developed measles 3 days before returning from
   Singapore/Sri Lanka and one developed measles 9 days after returning from
   Philippines.
   In Tokyo, 4 domestic sporadic cases; 2 each in February and March.
   In Saitama, one domestic sporadic case in February.
   In Kanagawa, 2 cases; one developed measles 7 days after returning from Philippines
   in January and a family member developed measles in February.
   In Okayama, one case in January who developed measles 8 days after returning from
   Philippines. 
   In Hiroshima, 9 cases during January-February; one developed measles one day after
   returning from Philippines followed by 6 contact cases and two domestic cases.
   In Kagawa, one case in February developed measles after returning from Hiroshima.
   In Osaka, one case in April developed measles on the day of arrival from Cambodia.
   In Hiroshima, a domestic sporadic case in April.
   In Tokyo, 2 cases in April; one developed measles 4 days after returning from
   Philippines and one developed measles after returning from Georgia.
   In Tokyo, 13 cases in May; 12 domestic sporadic cases and one case who developed
   measles 8 days after returning from Indonesia.
   In Chiba, 4 domestic sporadic cases in May.
   In Shizuoka, one case in June returning from Philippines.
   In Hyogo, one case in July who developed measles after returning from Philippines.
   In Aichi, one case in August developed measles 10 days after returning from Thailand/Indonesia.
   In Niigata, one case in September developed measles 3 days before a visit from Malaysia.
   In Tokyo, one case in October developed measles after a trip to Portugal via Malaysia and France.
[Genotype G3] 2 case; one case in February and one case in October.
   In Chiba, one developed measles 10 days after returning from Indonesia. 
   In Kagoshima, one case in October developed measles after returning from Indonesia.
[Genotype A (vaccine type)] 7 cases; 2 in January, one in February, one in May, 2 in June and one in July.
   In Tokyo, a exanthem case in January (from the specimen taken 13 days after
   vaccination).
   In Fukuoka, a measles-suspected case in January (from the specimen taken 10 days after
   vaccination). 
   In Niigata, a measles-suspected case in January (from the specimen taken 14 days after
   vaccination).
   In Nagano, a measles-suspected case in May (from the specimen taken 9 days after
   vaccination).
   In Tokyo, a measles-suspected case (from the specimen taken 9 days after vaccination)
   and a exanthem case (from the specimen taken after vaccination) in June.
   In Tokyo, a upper-respiratory inflammation case in July (from the specimen taken 13 days
   after vaccination).
2010
  From February to December 2010, PHIs in Tokyo Metropolitan and 10 prefectures (Hokkaido, Ibaraki, Chiba, Kanagawa, Aichi, Mie, Osaka, Yamaguchi and Fukuoka) reported 27 measles virus isolation/detection.
  In May, a genotype D5 virus was detected from a case in Chiba and genotype H1 viruses were detected from 2 cases (one in Hokkaido who developed measles during a visit from China and another in Ibaraki who developed measles 11 days after returning from China). 
  Genotype D9 viruses were detected from 16 cases from July to December; 12 cases in Aichi, 3 cases in an outbreak including two in July (one developed measles 3 days after returning from the Philippines and 11 days later another family member developed measles)and one in August (a contact case in the outpatient clinic), one in November (who developed measles 2 days after returning from the Philippines), 8 cases in an outbreak including one in November and 9 in December (the index case developed measles 6 days after returning from the Philippines) ; 2 cases in Mie, one each in August (who developed measles 3 days after returning from the Philippines) and in September (a domestic measles case). 
  In September, a genotype D8 virus was detected in Kanagawa from a case who developed measles 3 days after returning from India.
  In December, a genotype D4 virus was detected in Hokkaido from a case who developed measles 10 days after returning from India.
  In addition, genotype A (vaccine type) viruses were detected from 4 exanthem cases; two in Tokyo, one each in February (from the specimen taken 9 days after vaccination) and in March (history of vaccination is unknown); one in Fukuoka in June (from the specimen taken 11 days after vaccination); one in Yamaguchi in September (from the specimen taken 13 days after vaccination).  In Osaka, genotype A viruses were also detected from a measles-suspected case in September (from the specimens taken 12 days after vaccination) and a upper-respiratory inflammation case in October (from the specimens taken 16days after vaccination).
2009
  From February to September 2009, PHIs in Tokyo Metropolitan and 4 prefectures (Yamagata, Osaka, Fukuoka and Okinawa) reported 8 measles virus isolation/detection.
  Genotype D5 viruses were detected from 3 cases in Okinawa; 2 cases in February and a case in April.  In March, a genotype D9 virus was isolated in Yamagata from a case who developed measles 15 days after returning from Thailand (JJID 62: 481-482, 2009).
  In September, a genotype D8 virus was isolated for the first time in Japan from a domestic measles case in Okinawa.
  In addition, genotype A (vaccine type) viruses were detected from 3 cases; 2 cases in April, one from a chickenpox case in Tokyo and another from a herpangina case in Osaka (either history of vaccination is unknown), and a exanthem subitum case in June in Fukuoka (from the specimen taken 11 days after vaccination). 

Isolation/detection of measles virus in Japan, 2006-2008
Infectious Agents Surveillance Report, Infectious Disease Surveillance Center,
National Institute of Infectious Diseases

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